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A study from Vanderbilt University that appears in the Journal of Clinical Investigation reveals that marijuana use at the time of conception and early in pregnancy prevents embryos’ safe passage from the ovary to the uterus, resulting in early pregnancy failure.

Marijuana, the most widely used illegal drug among women of reproductive age, binds to 2 receptors — cannabinoid receptors 1 and 2 (CB1, CB2) — which are found in the brain and other organs including sperm, eggs, and newly formed embryos. Normally, these 2 receptors are activated by the naturally occurring signaling molecule anandamide. Anandamide formation by the enzyme NAPE-PLD is carefully balanced with its degradation by the enzyme FAAH, resulting in a finely tuned local “anandamide tone” in embryos and the oviduct. This balance is required for normal embryonic development, transport along the oviduct, implantation in the uterus, and full-term pregnancy.

The results of the study show that drugs such as THC persist and swamp these finely tuned signaling systems and as such the use of THC-containing drugs such as marijuana may lead to ectopic pregnancy and/or impaired fertility in women.

A commentary from Herbert Schuel from the State University of New York discusses the sobering results of this study regarding marijuana’s effects on pregnancy outcome and goes on to stress that a number of drugs currently in development or in use to suppress appetite or trigger weight-loss are also potential problems and “such drugs need to be carefully evaluated to judge their effects on women of reproductive age and those that are pregnant.”

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