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Researchers led by Nora D. Volkow, MD, director of the National Institute on Drug Abuse (NIDA), report evidence that Provigil (generic name, modafinil) might be more addictive than thought.

The study was published in the March issue of the Journal of the American Medical Association (JAMA).

“There is an increasing use of this medication, and people have promoted the off-label use of stimulants and Provigil as cognitive enhancers with the belief that these drugs are safe”. “But these drugs have side effects, and their use without proper medical oversight could lead to abuse and addiction.”

The new study is the first human evidence that a typical dose of modafinil affects dopamine in the brain as much as a dose of Ritalin, a controlled substance with clear potential for dependence. College students buy and sell it illegally, as they do Ritalin and Adderall, to stay alert while studying.

Provigil is FDA approved for promoting wakefulness in people with narcolepsy, sleep apnea, and shift work sleep disorder. It is classified by the Drug Enforcement Administration as a Schedule IV drug.

It has been on the market since 1999 from Cephalon Inc. of Frazer, Pa., and its sales approached $1 billion last year!

More info: http://jama.ama-assn.org

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